Listen to our four incredible panelists Prof. Marian Knight on the UK national cohort study, Prof. Tim Spector on the ZOE study, Prof. Yves Ville on vertical transmission and Prof. Neena Modi on neonates.
Overview
Why attend?
Learning objectives:
- Learn about the outcomes of pregnant women from the UK national cohort study
- Hear how to predict infection without a test
- Understand more about the ZOE study with over 3 million participants
- Hear the latest research on vertical transmission
- Know more about neonatal infection and the data behind this
- Ask questions to the expert panel
Watch now
Coronavirus: Outcomes, predictions and infection: from mother through to the neonate
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Program and presentations
Program
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Time
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Talk
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Speaker
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11.00-11.05
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Welcome and introduction
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Prof. Tom Bourne
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11.05-11.15
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The full symptom complex of COVID19: how to predict infection without a test. Lessons from the ZOE study of over 3 million participants
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Prof. Tim Spector
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11.15-11.25
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Outcomes of pregnant women hospitalised with confirmed SARS-CoV-2 - data from the UK national cohort study
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Prof. Marian Knight
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11.25-11.35
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Update on the evidence for vertical transmission for SARs-CoV-2
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Prof. Yves Ville
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11.35-11.45
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Neonatal aspects of SARs-CoV-2 infection and data collection to inform our understanding
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Prof. Neena Modi
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11.45-12.30
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Moderated panel Q&A
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Moderated by Prof. Tom Bourne, Prof. Christoph Lees and Prof. Liona Poon
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Presentations
(to find out more about the UK COVID Symptom Study app, click here)
Neonatal aspects of SARs-CoV-2 infection and data collection to inform our understanding
Faculty
Professor Tom Bourne
ISUOG President 2020 - 2022, Virtual World Congress Technical Congress Chair 2020 and 2021, 2022 World Congress Co-Chair, Executive Committee, Finance & Risk Committee, Nominations Committee
Professor Tom Bourne was ISUOG President between 2020 and 2022 and is curently Chair in Gynaecology at Imperial College London, Hon Consultant Gynaecologist at Queen Charlottes and Chelsea hospital and Visiting Professor at KU Leuven in Belgium. He is an authority on managing early pregnancy complications, emergency gynaecology and gynaecological ultrasonography. He trained in ultrasound at Kings College Hospital in London. He subsequently worked at the University of Göteborg, Sweden as Medical Research Council visiting scientist, Hamar in Norway, and Leuven in Belgium. He was appointed senior lecturer and consultant gynaecologist at St George's University Hospital London before moving to Imperial College. He has edited seven books and published over 400 papers. He sits on the management committee of the Tommy’s National Centre for Miscarriage Research. He is medical advisor and trustee of the patient group, the Ectopic Pregnancy Trust. He is immediate Past-President of the UK Association of Early Pregnancy Units. He is co-founder and CEO of the International Ovarian Tumor Analysis (IOTA) group and sits on the steering committees of several large multicentre international trials. He is founder member of the RCOG task force on “supporting our doctors”. He is honorary fellow of the American Institute of Ultrasound in Medicine, honorary member of the Australasian Society for Ultrasound in Medicine and honorary member of the Brazilian and Hungarian Ultrasound Societies.
His principal research interest is diagnostics in early pregnancy and gynaecology including the IOTA, IETA, IDEA and MUSA studies, microbiome, metabolomics, novel biomarkers, and AI. His interests include the psychology of pregnancy loss and physician welfare including studies with the BMA and RCOG.
Country: UK
Language: English
Field: Gynaecology
Specialties: Early Pregnancy Care, Emergency Gynaecology, Ultrasound in Oncology, Gynaecological Ultrasonography, Physician Wellbeing
Selected Notable Publications:
Sporadic miscarriage: evidence to provide effective care. Coomarasamy A, Gallos ID, Papadopoulou A, Dhillon-Smith RK, Al-Memar M, Brewin J, Christiansen OB, Stephenson MD, Oladapo OT, Wijeyaratne CN, Small R, Bennett PR, Regan L, Goddijn M, Devall AJ, Bourne T, Brosens JJ, Quenby S.
Lancet. 2021 May 1;397(10285):1668-1674. doi: 10.1016/S0140-6736(21)00683-8. Epub 2021 Apr 27.
Van Calster B, Valentin L, Froyman W, Landolfo C, Ceusters J, Testa AC, Wynants L, Sladkevicius P, Van Holsbeke C, Domali E, Fruscio R, Epstein E, Franchi D, Kudla MJ, Chiappa V, Alcazar JL, Leone FPG, Buonomo F, Coccia ME, Guerriero S, Deo N, Jokubkiene L, Savelli L, Fischerová D, Czekierdowski A, Kaijser J, Coosemans A, Scambia G, Vergote I, Bourne T, Timmerman D.
BMJ. 2020 Jul 30;370:m2614. doi: 10.1136/bmj.m2614.
Farren J, Jalmbrant M, Falconieri N, Mitchell-Jones N, Bobdiwala S, Al-Memar M, Tapp S, Van Calster B, Wynants L, Timmerman D, Bourne T.
Am J Obstet Gynecol. 2020 Apr; 222(4):367.e1-367.e22. doi: 10.1016/j.ajog.2019.10.102.
Froyman W, Landolfo C, De Cock B, Wynants L, Sladkevicius P, Testa AC, Van Holsbeke C, Domali E, Fruscio R, Epstein E, Dos Santos Bernardo MJ, Franchi D, Kudla MJ, Chiappa V, Alcazar JL, Leone FPG, Buonomo F, Hochberg L, Coccia ME, Guerriero S, Deo N, Jokubkiene L, Kaijser J, Coosemans A, Vergote I, Verbakel JY, Bourne T, Van Calster B, Valentin L, Timmerman D.
Lancet Oncol. 2019 Mar; 20(3): 448-458. doi: 10.1016/S1470-2045(18)30837-4.
Defining safe criteria to diagnose miscarriage: prospective observational multicentre study. Preisler J, Kopeika J, Ismail L, Vathanan V, Farren J, Abdallah Y, Battacharjee P, Van Holsbeke C, Bottomley C, Gould D, Johnson S, Stalder C, Van Calster B, Hamilton J, Timmerman D, Bourne T.
BMJ. 2015 Sep 23; 351:h4579. doi: 10.1136/bmj.h4579.
Evaluating the risk of ovarian cancer before surgery using the ADNEX model to differentiate between benign, borderline, early and advanced stage invasive, and secondary metastatic tumours: prospective multicentre diagnostic studies. Van Calster B, Van Hoorde K, Valentin L, Testa AC, Fischerova D, Van Holsbeke C, Savelli L, Franchi D, Epstein E, Kaijser J, Van Belle V, Czekierdowski A, Guerriero S, Fruscio R, Lanzani C, Scala F, Bourne T, Timmerman D; International Ovarian Tumour Analysis Group.
BMJ. 2014 Oct 15;349:g5920. doi: 10.1136/bmj.g5920.
Diagnostic criteria for nonviable pregnancy early in the first trimester. Doubilet PM, Benson CB, Bourne T, Blaivas M; Society of Radiologists in Ultrasound Multispecialty Panel on Early First Trimester Diagnosis of Miscarriage and Exclusion of a Viable Intrauterine Pregnancy, Barnhart KT, Benacerraf BR, Brown DL, Filly RA, Fox JC, Goldstein SR, Kendall JL, Lyons EA, Porter MB, Pretorius DH, Timor-Tritsch IE.
N Engl J Med. 2013 Oct 10; 369(15): 1443-51. doi: 10.1056/NEJMra1302417.
Limitations of current definitions of miscarriage using mean gestational sac diameter and crown-rump length measurements: a multicenter observational study. Abdallah Y, Daemen A, Kirk E, Pexsters A, Naji O, Stalder C, Gould D, Ahmed S, Guha S, Syed S, Bottomley C, Timmerman D, Bourne T.
Ultrasound Obstet Gynecol. 2011 Nov; 38(5): 497-502. doi: 10.1002/uog.10109.
He is President of the UK Association of Early Pregnancy Units (AEPU), Trustee of the Ectopic Pregnancy Trust and on the steering committee of the International Ovarian Tumor Analysis (IOTA) trial.
Honorary Consultant in Public Health, Public Health England
Perinatal Doppler and Vascular Focus Group (Chair), UOG Editorial Board
Christoph Lees is Professor of Obstetrics as Imperial College London; Honorary Consultant in Obstetrics and Head of Specialty for Fetal Medicine at the Centre for Fetal Care, Queen Charlotte’s and Chelsea Hospital, Imperial College Healthcare NHS Trust; Clinical Director for Fetal Medicine for North West London and Visiting Professor KU Leuven (Belgium). His research interest is on fetal assessment and in particular the use of Doppler ultrasound to assess the health of the baby, scanning in labour, and non-invasive fetal surgery. He is the Chief Investigator of The Trial of Umbilical and Fetal Flow in Europe (TRUFFLE), a Collaboration of 51 Centres across Europe; co-founder of the International Working Group of Maternal Haemodynamics and Intrapartum ultrasound ISLANDs group. He was awarded £2.2m grant from the Medical Research Council for first in human studies of high-intensity focused ultrasound in 2017, a £2.5m grant from the NIHR in 2019 to undertake the TRUFFLE 2 RCT and a £2.1M grant from the NIHR for a study on ultrasound of breech pregnancy at 36 weeks in 2023.
Country: UK
Field: Obstetrics
Specialties: Fetal anomaly screening T2; fetal biometry and wellbeing; aneuploidies; fetal anomalies; fetal growth restriction; maternal and fetal Doppler; preeclampsia; safety of ultrasound
Language: English
Field: Obstetrics
Specialties: Fetal anomaly screening T2; fetal biometry and wellbeing; aneuploidies; fetal anomalies; fetal growth restriction; maternal and fetal Doppler; preeclampsia; safety of ultrasound
Language: English
Honorary Consultant, Neonatal Medicine at Chelsea and Westminster NHS Foundation Trust
Executive Committee, Finance & Risk Committee, Nominations Committee, China Task Force, UOG Editorial Board
Professor Liona Poon is an Academic Subspecialist in Maternal Fetal Medicine, devoted in improving maternal and fetal health. She has had a prolific research output throughout her clinical and research posts, including over 130 peer-reviewed publications in high impact international journals. In the last 10 years she has focused her research on establishing a programme for effective early prediction and prevention of preeclampsia, a major cause of maternal and perinatal morbidity and mortality. With her success in developing a first-trimester prediction model for preeclampsia using maternal risk factors, ultrasound, blood pressure and biochemical markers, and on Aspirin prophylaxis against preeclampsia, her goal in the next 10 years is to improve obstetric care worldwide, through clinical research and education.
Notable Publications:
Aspire trial: incidence of preterm preeclampsia in patients fulfulling ACOG and NICE criteria according to risk by the FMF algorithm. Poon LC, Rolnik DL, Tan MY, Delgado JL, Tsokaki T, Akolekar R, Singh M, Andrade W, Efeturk T, Jani JC, Plasencia W, Papaioannou G, Blazquez AR, Carbone IF, Wright D, Nikolaides KH.
Ultrasound Obstet Gynecol 2018 Jan 30. doi: 10.1002/uog.19019 [Epub ahead of print]
Aspirin versus Placebo in Pregnancies at High Risk of Preterm Preeclampsia. Rolnik DL, Wright D, Poon LC, O'Gorman N, Syngelaki A, de Paco Matallana C, Akolekar R, Cicero S, Janga D, Singh M, Molina FS, Persico N, Jani JC, Plasencia W, Papaioannou G, Tennebaum Gavish K, Meiri H, Gizurarson S, Maclagan K, Nicolaides K.H.
New England Journal Medicine 2017, 2017 Jun 28. doi: 10.1056/NEJMoa1704559. [Epub ahead of print]
Country: China, Hong Kong Special Administrative Region
Field: Obstetrics
Specialties: Fetal anomaly screening 1st trimester and 2nd trimester; fetal biometry and wellbeing; fetal anomalies screening; aneuploidy screening; fetal anomalies; fetal growth restriction; maternal and fetal Doppler; multiple pregnancy; preeclampsia; preterm delivery; fetal growth; detection of fetal and neonatal growth abnormalities; ultrasound on the labour ward
Languages: English; Chinese (Mandarin); Chinese (Cantonese)
He trained originally in rheumatology and epidemiology. In 1992 he moved into genetic epidemiology and founded the UK Twins Registry, of 13,000 twins, which is the richest collection of genotypic and phenotypic information worldwide. He is past President of the International Society of Twin Studies, directs the European Twin Registry Consortium (Discotwin) and collaborates with over 120 centres worldwide. He has demonstrated the genetic basis of a wide range of common complex traits, many previously thought to be mainly due to ageing and environment. Through genetic association studies (GWAS), his group have found over 500 novel gene loci in over 50 disease areas. He has published over 800 research articles and is ranked as being in the top 1% of the world’s most cited scientists by Thomson-Reuters as well as the most cited scientist at King’s College London. He held a prestigious European Research Council senior investigator award in epigenetics and is a NIHR Senior Investigator and is a Fellow of the UK Academy of Medical Sciences. His current work focuses on omics and the microbiome and directs the crowdfunded British Gut microbiome project. He is a prolific writer with several popular science books and a regular blog, focusing on genetics, epigenetics and most recently microbiome and diet (The Diet Myth). He is in demand as a public speaker and features regularly in the media.
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Professor Yves Ville is Professor and Chairman of the Department of Obstetrics and Fetal Medicine at Necker-Enfants-Malades Hospital at the Paris Descartes University. He is the Chair and lead clinician in the largest fetal medicine and therapy unit in France. He has pursued a platform of work that has allowed clinical and academic progress of the subspecialty of fetal medicine, both nationally and internationally.
Country: France
Field: Obstetrics; Fetal Medicine
Specialties: Fetal anomaly screening T1; fetal anomalies; fetal brain; fetal growth restriction; fetal interventional procedures; multiple pregnancy; preterm delivery; genetics
Languages: English; French