Understand the latest research and clinical best practice on early pregnancy care.
Ultrasound plays a pivotal role in early pregnancy, providing clinicians and their patients critical information on gestational viability, location, and fetal development. Ultrasound imaging is essential for confirming intrauterine pregnancy, assessing gestational age, detecting multiple gestations, and identifying early complications such as ectopic pregnancy or miscarriage. Transvaginal ultrasound offers superior resolution in the first trimester, enabling precise evaluation of embryonic structures, early cardiac activity and in expert hands morphological assessment. Early ultrasound combined with non-invasive prenatal testing is changing the framework of risk assessment for chromosomal abnormalities and fetal anomalies, guiding clinical management from the earliest stages of pregnancy.

The very early anatomy scan.
Meagher, S. (2022, September 18).

The very early anatomy scan.
Meagher, S. (2022, September 18).

The very early anatomy scan.
Meagher, S. (2022, September 18).

Diagnosing and managing caesarean scar pregnancy.
Jurkovic, D. (2025, February 7).

Diagnosing and managing caesarean scar pregnancy.
Jurkovic, D. (2025, February 7).
Why is early pregnancy a key topic at ISUOG 2025?
Recent UOG articles
- Accuracy of cell-free fetal DNA in detecting chromosomal anomalies in women experiencing miscarriage: systematic review and meta-analysis - L. Della Valle, M. Piergianni, A. Khalil, G. Rizzo, I. Mappa, B. Matarrelli, A. Lucidi, L. Manzoli, M. E. Flacco, L. Stuppia, F. D'Antonio. First published: 07 December 2024
- Biparietal diameter vs crown–rump length as standard parameter for late first-trimester pregnancy dating - H. K. Gjessing, P. Grøttum, J. M. Dreier, S. H. Eik-Nes. First published: 24 October 2024
- Uterine fibroids and non-informative cell-free DNA screening results - D. L. Rolnik, Y. Raymond, T. Lee, J. Ramkrishna, F. da Silva Costa, M. Menezes, S. Meagher. First published: 23 August 2024
- Adverse pregnancy outcome in fetuses with early increased nuchal translucency: prospective cohort study - B. B. Bet, M. A. Lugthart, I. H. Linskens, M. C. van Maarle, E. van Leeuwen, E. Pajkrt. First published: 27 February 2024
- Amniotic sac diameter reference interval in early pregnancy between 7 and 10 weeks' gestation - S. A. Solangon, S. Nijjar, L. V. De Braud, J. Knez, L. Berg, E. Jauniaux, D. JurkovicFirst published. 27 January 2024
- Safety of methotrexate administration in women with pregnancy of unknown location at high risk of ectopic pregnancy - C. S. Jin, C. Uzuner, G. Condous. First published: 27 January 2024
Supplement your learning
Lectures
Avoiding diagnostic error in early pregnancy - T. Bourne
Diagnosing and managing caesarean scar pregnancy - D. Jurkovic
Shifting the algorithm of aneuploidy and anatomy before 11 weeks - D. Rolnik
The very early anatomy scan: 6 to 10 weeks - S. Meagher
VISUOG
Normal Early Pregnancy
Early pregnancy ultrasound plays an important role in confirmation of pregnancy, establishing viability and location of the pregnancy, confirming fetal number and type of placentation in multiple pregnancy and facilitating early diagnosis of life-threatening abnormalities such as ectopic or molar pregnancy. In this chapter, we will provide the reader with key information on the value of early pregnancy ultrasound.
Pregnancy of unknown location (PUL)
A PUL is defined as occuring when a patient tests positively for pregnancy but the initial transvaginal ultrasound scan is not able to locate the pregnancy. It is currently believed that the best way to manage these cases is by performing risk prediction, for which hCG and progesterone are used as biomarkers.
Cesarean scar pregnancy
Cesarean scar pregnancy (CSP) is an abnormal implantation of the gestational sac in the area of the prior caesarean delivery (CD) scar, potentially leading to life-threatening complications, including severe haemorrhage, uterine rupture and development of placenta accreta spectrum (PAS) disorders.
Cervical Ectopic Pregnancy
Cervical ectopic pregnancy refers to an abnormal implantation of a fertilized ovum within the myometrium below the level of the internal os with a reported incidence of less than 1% of all ectopic pregnancies.
Intramural Ectopic Pregnancy
Intramural ectopic pregnancy refers to an abnormal implantation of a pregnancy within the myometrium. A gestational sac extending beyond the endometrial-myometrial junction is the defining feature. Intramural ectopic pregnancies should be subdivided into partial and complete. Ultrasound is the first-hand diagnostic tool.
Ovarian ectopic pregnancy
Ovarian ectopic pregnancy (OEP) is a rare type of ectopic pregnancy in which the fertilized ovum implants into the ovary.
Tubal Ectopic Pregnancy
An ectopic pregnancy is defined as the presence of a pregnancy outside the uterine cavity, the commonest location being the fallopian tube. They account for 1-2% of pregnancies in the UK and may be as high as 4% with assisted conception.
Interstitial Ectopic Pregnancy
Interstitial ectopic pregnancy is defined as the ectopic gestation implanting in the most proximal part of the fallopian tube.
Patients information
Normal early pregnancy ultrasound
This leaflet is to help you understand the use and goals of early pregnancy ultrasound, how to prepare for it, and what to watch out for.
Cesarean scar pregnancy
This leaflet is to help you understand more about Cesarean scar pregnancy.
Cervical Ectopic Pregnancy
This leaflet is to help you understand what cervical ectopic pregnancy is, how cervical ectopic pregnancy happens, what the symptoms are, and the recurrence for the next pregnancy.
Interstitial Ectopic Pregnancy
This leaflet is designed to help you understand what interstitial ectopic pregnancy (IEP) is, how it happens, what the symptoms are, and the risk of recurrence.
Intramural Ectopic Pregnancy
This leaflet is to help you understand what Intramural Ectopic Pregnancy is, what tests you need and the implication of being diagnosed for you, your baby and your family.
Ovarian Ectopic Pregnancy
This leaflet is to help you understand what an ovarian ectopic pregnancy is, what tests you need and the implication of being diagnosed are for you, your baby and your family.
Rudimentary Horn Pregnancy
This leaflet is to help you understand what rudimentary-horn-pregnancy is, what tests you need and the implication of being diagnosed for you, your baby and your family.
Tubal Ectopic Pregnancy
This leaflet is to help you understand Tubal Ectopic Pregnancy.
Pregnancy of unknown location or PUL
This leaflet is to help you understand what Pregnancy of Unknown Location (PUL) is, what are its symptoms, what tests do you need, and what should you be watching out for.
First-trimester Anatomy of the Abdomen
This leaflet is to give you an overview and understand what's involved during the first-trimester ultrasound examination of the fetal abdomen.
CME activities
- CME Activity: Caesarean Section Scar Pregnancy: Updates on Diagnosis and Management
- CME Activity: Early First Trimester Detection of Fetal Malformation 8-11 Weeks
- CME Activity: Do Events in Early Pregnancy Impact on Long-Term Pregnancy Outcome?
- CME Activity: Miscarriage Diagnosis: Are the New Ultrasound Cut-Offs Conservative Enough?
Questions
How early can ultrasound reliably detect a viable intrauterine pregnancy?
What are the most accurate sonographic markers for predicting early pregnancy failure?
What are the limitations of transabdominal versus transvaginal ultrasound in early gestation?
How reliable is early pregnancy ultrasound for detecting adverse outcomes that present later in gestation?
What role does 3D/4D ultrasound play in early pregnancy assessment?
How can artificial intelligence enhance early pregnancy ultrasound interpretation?